...
REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE("Physical Item Details"."Modified By",'910135016','HN'),'915144202','LF'),'908663101','CDC'),'909413966','MRTL'),'915252914','MKD'),'910061693','CP'),'907604594','YL'),'915628432','HT'),'909818183','EL'),'916241818', 'ECEGC')
You can add replacement functions to this by appending ,'USERID','INITIALS') and prepending REPLACE(